文献标题


International network of cancer genome projects (ICGC)

PMID

20393554

发表日期

2010-04-15

关键词

  • ICGC
  • Cancer Project

概括

The International Cancer Genome Consortium (ICGC) 是一个非常重要的大样本肿瘤研究项目。

目标是涵盖50个癌症类型/亚型, 每个亚型500个样本, 共2万5千例肿瘤样本, 截止2017年9月共有18个国家参加,部分项目也同时属于TCGA

好词好句

单词

  • non-neoplastic tissues (正常组织)
  • somatic epigenetic ‘marks’
  • CpG dinucleotides
  • comprehensiveness
  • the state of methylation of CpG dinucleotides.
  • franchise (特权)
  • publication moratorium (发布禁令)

句子

  • Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels
  • A subset of the somatic mutations in cancer cells confers oncogenic properties such as growth advantage, tissue invasion and metastasis, angiogenesis, and evasion of apoptosis
  • The challenges of the ICGC are daunting owing to the scope of the initiative, the complexity that is inherent to the heterogeneity of cancer, and the limitations of current technologies to provide accurate long range assemblies of highly rearranged chromosomes found in tumour cells.

笔记


ICGC Goals

靶向药物治疗的例子:

trastuzumab for HER2 (also known as NEU or ERBB2)-positive breast cancers. imatinib for BCR-ABL

肿瘤潜在治疗靶点的例子:

PIK3CA14, BRAF15, NF1 , KDR10, PIK3R1, and histone methyltransferases and demethylases

Passengers mutation:

Somatic mutations that do not contribute to cancer development

Cancer genome projects:

United States (The Cancer Genome Atlas) United Kingdom (Cancer Genome Project)

为什么要开展ICGC这个国际项目?

  • 扩大影响范围
  • 独立项目可能会导致重复、不完整的研究
  • 缺乏统一标准,使得独立项目数据不太容易被整合
  • 癌症是全世界共同需要面对的问题
  • 国际项目可以加速数据的传播和生物信息分析方法的开发(社区)

如何才能得到高质量的肿瘤研究数据?

  • 尽可能多地获得高频特征(如>3%的体细胞变异)
  • 高分辨率(单核苷酸水平)
  • 标准统一(建库、测序等等)
  • 有与肿瘤组织匹配的正常对照
  • 尽可能多的在同一肿瘤细胞、组织中产生不同维度的数据(基因组、转录组、表观组等等)

ICGC数据仓库:

ICGC Data Coordination Center (DCC)


DDC